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Despite their common etiology, DFTD and CTVT have evolved independently and have unique life histories and host adaptations.

DFTD is a recently emerged aggressive facial tumor that is threatening the Tasmanian devil with extinction.

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Lesions associated with DFTD were first observed in devils in northeastern Tasmania in 1996 (Hawkins et al., 2006).Cancer arises when a single-cell lineage acquires somatic mutations that promote it toward a program of continued proliferation.Natural selection favors the most prolific subclones, often steering the cancer toward a more aggressive phenotype.DFTD and CTVT are the only known naturally occurring clonally transmissible cancers, and although they share a number of common features, they have emerged independently and have strikingly different life histories.

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