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Despite their common etiology, DFTD and CTVT have evolved independently and have unique life histories and host adaptations.

DFTD is a recently emerged aggressive facial tumor that is threatening the Tasmanian devil with extinction.

The project is reportedly being shaped to accommodate director Andy Muschietti, whose work on the reboot film of Stephen King horror classic It has been widely met with praise in its early reviews.

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Lesions associated with DFTD were first observed in devils in northeastern Tasmania in 1996 (Hawkins et al., 2006).Cancer arises when a single-cell lineage acquires somatic mutations that promote it toward a program of continued proliferation.Natural selection favors the most prolific subclones, often steering the cancer toward a more aggressive phenotype.DFTD and CTVT are the only known naturally occurring clonally transmissible cancers, and although they share a number of common features, they have emerged independently and have strikingly different life histories.



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