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Final results should help the understanding of the molecular physiology of Leydig cells in the stress response of the organism as a whole. Andric SA, Zivadinovic D, Gonzalez-Iglesias AE, Lachowitcz A, Tomic M & Stojilkovic SS (2005): Endothelin-induced long lasting and Ca2 influx-independent blockade of intrinsic secretion in pituitary cells by Gz subunits. LEADING OF PROJECTS • Reinforcement of Research Potential of the Laboratory for Ecotoxicology (Rep-Lecotox) Contract No.: INCO-CT-2006-043559-REP-LECOTOX, financed by the European Commission within The Sixth Framework Programme (FP6) of the European Union. Radmila Kovačević, Faculty of Sciences, Novi Sad Period: January 2007 – December 2009.
(2008) Cold hardening processes in the Antarctic springtail Cryptopygus antarcticus: Clues from a microarray, Journal of Insect Physiology, Vol. • Molecular physiology of Leydig cells in response to stress (APV0667) The project is co-funded by the Provincial Secretariat for Science and Technological Development of the AP Vojvodina. The results demonstrated the importance of the “cross-talk” communication between c AMP and c GMP signaling, as well as of mitochondrial dynamics and stereogenesis in the synchronization of the function of Leydig cells and development of an adaptive response. Kostic TS, Andric SA & Stojilkovic SS (2004): Receptor-controlled phosphorylation of a1 soluble guanylyl cyclase enchances nitric oxide-dependent cyclic guanosine 5’-monophosphate production in pituitary cells. All LECOTOX activities are carried out in accordance with the principles of good laboratory practice (GLP), observing ethical standards.
In such conditions, the survival is guaranteed only due to the timely response to the current requirements of the environment. • Methods of studying enzyme activity and kinetics. Light and electron microscopic study of the thyroid gland in rats exposed to powerfrequency electromagnetic fields. LEADING OF PROJECTS • Monitoring of the status of the thyroid gland in the treatment of postmenopausal experimental osteoporosis Project No.: 114-451-01426. The project was carried out in the cooperation with the Institute of Physical Medicine, Rehabilitation and Balneo-Climatology “Mlječanica”, Kozarska Dubica, Republic of Srpska.
Maintenance of homeostasis, as the harmonization of numerous biochemical reactions and physico-chemical processes in living systems under variable environmental conditions, is a main prerequisite of life. • Methods of characterization of mitochondria (TMRE assay; Mito Track assay). The Laboratory for Histology and Embryology has at its disposal the equipment for treatment of tissue samples and their routine and immunohistochemical staining (rotational microtome, ultramicrotome and other accompanying standard equipment needed for the work in a histological laboratory). International Journal of Radiation Biology 81(7):491-499.
7 Members of Academies of Sciences from the Faculty of Sciences .
8 Tokens of Recognition and Awards for Scientific Achievements .
2 – CT2002 – 10007 • Wallac 1410-scintillation counter, Project IAEA, Year: 1990.
121/2002 • Fluoroskan Ascent and Multiscan Plate reader (Thermo–Labsystems); FP5 project APOPSBAL Grant No.
Rapid development of the methods based on gene expression and their application in elucidating hot ecotoxicological problems such as the mechanism of toxic action, but also very intensive international cooperation and exchange of information in this area – all these issues indicate the importance of the topic and justify the decision of LECOTOX to direct permanently its activities in this direction. (2008): In vivo and in vitro effects of PCB126 and PCB153 on rat testicular androgenesis. The expected results are: (a) Closer definition of the mechanisms of potential negative action of selected substances; (b) Development of the methodology of identification and overall assessment of the state of the environment, with the emphasis on potential ecotoxicity using alternative approach, where the results of bioanalysis govern detailed chemical analysis and characterization of the samples. Andric N., Kostic T., Kaisarevic S., Fa S., Pogrmic K., Kovacevic R. Bulletin of Environmental Contamination and Toxicology 79, 422-426. Part of the research group of the Laboratory for Biochemistry and Molecular Biology in the Arctic (Ny Alesund) within the FP6 project 16 Department of Biology and Ecology SELECTED REFERENCES Members of the Laboratory for Biochemistry and Molecular Biology PARTICIPATION IN PROJECTS • Sleeping beauty, Dormancy of cells and organisms-strategies for survival and preservation, The Sixth Framework Programme of European Union (FP6); Project No.: FP6-2003-NEST-B-1, 2005-2008. Gordana Grubor-Lajšić, Faculty of Sciences, Novi Sad. Andric SA, Kostic TS & Stojilkovic SS (2006): Contribution of multidrug resistance protein - MRP5 in control of c GMP intracellular signaling in anterior pituitary cells. R esearch activities of the RES group take place in several areas: cell signaling, reproductive endocrinology, immobilization stress. Lažetić B., Kasaš-Lažetić K., Matavulj M., Pekarić-Nadj N., Rajković V. Fundamentals of Magnetobiology – a monograph, Ed.: Lažetić B., University of Novi Sad, Novi Sad.